Kev siv cov khoom siv hlau hauv kev lag luam kho mob yuav tsum tsis muaj kev phom sij rau tib neeg lub cev. Thaum cov hlau corrosion, nws muaj peev xwm yaj hlau ions, rau cov kab mob (tib neeg lub cev) ntawm lub cellular lub koom haum ntawm cov kev cuam tshuam, yog li nws yog tsim nyog los xaiv tsis yooj yim rau corrode, siab corrosion-resistant hlau cov ntaub ntawv, titanium yog ib hom siab. corrosion-resistant cov ntaub ntawv. Kev kho mob hlau cov ntaub ntawv los ntawm stainless hlau series mus rau cobalt-based thiab titanium-raws li alloy series, titanium thiab titanium alloy piv yog nce. Tus nqi ntawm titanium siv hauv kev lag luam kho mob thoob ntiaj teb yog li 1, 000 tons hauv ib xyoos.
Txhawm rau soj ntsuam cov lus teb ntawm cov hlau ions rau tib neeg lub cev hloov kho, txoj kev ntsuas kev hloov pauv ntawm tes tau ua nyob rau hauv chav kuaj siv cov hlwb nkag siab rau cov hlau ions, xws li nas ntsws fibroblasts (V79 hlwb) thiab nas (20-hnub- qub nas) cov ntaub so ntswg fibroblast (I929 hlwb), uas yog siv rau kev sim kho mob hauv Suav teb, thiab los ntawm Independent Administration Institution of Product Evaluation Technology (IAIPET). Peb tau muab faib cov elemental monomer ions muab los ntawm Pawg Neeg Saib Xyuas Kev Ua Haujlwm rau Kev Ntsuas Kev Ntsuas Kev Ntsuas Txog Kev Kho Mob (TCSBMD) ua peb pawg raws li qhia hauv daim duab 1 los ntawm lawv cov kev cuam tshuam rau tib neeg lub cev (cov kab mob nyob).
Vanadium (V), npib tsib xee (Ni), thiab tooj liab (Cu) tau lees paub tias muaj tshuaj lom heev, thiab kev tuag ntawm tes tshwm sim nyob rau lub sijhawm luv luv ntawm qhov sib xyaw ntawm ib lab (×{{0}}) ntawm cov ntsiab lus no. Cov txiaj ntsig ntawm kev sim nrog vanadium (V) thiab npib tsib xee (N) hauv V79 hlwb tau pom nyob rau hauv daim duab 2. Cov txiaj ntsig ntawm kev sim rau ib lub lim tiam pom tau tias txhua lub hlwb tuag thaum nickel nyob ib puag ncig 10 ×10-6 ( pm=ntu ib lab), thaum vanadium (V) yog ob tug lej tsawg, thiab tag nrho cov hlwb tuag thaum vanadium nyob ib ncig ntawm 0.6 × 10-6. Qhov thib ob, thaum cov ntaub so ntswg (pob txha) thiab cov nqaij mos (sinews) ntawm cov tsiaj me, xws li nas thiab luav, tau muab faus rau hauv cov ntawv hlau rau kev kuaj, nws paub tseeb tias cov tshuaj lom no ua rau necrosis hauv cov ntaub so ntswg (pob txha) thiab cov nqaij mos (sinews) nyob rau hauv qhov chaw sib cuag.
a-V79 cell pejxeem tsim lub zog nyob rau hauv relation to nickel (Ni) ion concentration.
b-V79 cell pejxeem tsim lub zog piv rau vanadium (V) ion concentration.
Lwm pab pawg yog qhia tias yuav raug mob, nyob rau hauv lub xeev ntawm implantation thiab txuas, nyob rau hauv cov ntaub so ntswg fibrous ntawm qhov chaw sib cuag, tsim ib hom biomass cov tshuaj tiv thaiv kom tawm mus rau sab nraud ntawm lub cev, thiab qhov no yog cov hlau, aluminium, kub, nyiaj, thiab lwm yam. Cov khoom siv hlau dav dav xws li SUS 304L stainless hlau thiab SUS 36L stainless hlau nrog rau cobalt-chromium alloys yog hom no. Cov khoom hlau uas tau muab tso rau hauv cov ntaub so ntswg tawv, uas tsis fused nrog cov pob txha hlwb, raug tshem tawm kom du thiab tsis muaj zog thaum qhov kev tshem tawm tau ua ob peb lub lis piam tom qab.
Cov pab pawg thib peb muaj cov tshuaj tiv thaiv tsawg tshaj plaws nrog cov kab mob nyob thiab tsim nyog rau kev cog thiab txuas ntawm titanium, zirconium, niobium, tantalum, platinum thiab lwm yam. Thaum cov hlau no tau cog rau hauv lossis txuas nrog cov kab mob uas muaj sia nyob, lawv txuas nrog rau cov tawv nqaij tawv thiab mos, thiab ua rau somatized.
Raws li qhov tshwm sim, titanium yog cov hlau muaj kev nyab xeeb vim tias nws tsis tshua muaj kev raug mob rau cov kab mob nyob. Thaum siv cov titanium alloys, cov alloying ntsiab siv yog tsawg corrosion resistant tshaj titanium ntshiab, thiab thaum corrosion tshwm sim, cov alloying ntsiab yog yaj. Nws yog ib qho tsim nyog los xaiv cov alloying ntsiab lus uas yog corrosion-resistant thiab tsis-invasive. Hauv titanium alloys, Ti-6AI-4V alloy tau siv tau ntev hauv kev tsim dav hlau thiab cov khoom siv dej hiav txwv-resistant engineering, thiab muaj ntau qhov piv txwv ntawm kev siv. Hauv kev kho mob, ELI alloys, uas muaj qhov zoo corrosion kuj (tsawg hlau, oxygen, thiab hydrogen cov ntsiab lus), tau siv ntev. Tsis ntev los no, txawm li cas los xij, ua ib feem ntawm kev tshawb fawb thiab kev tsim cov titanium alloys rau kev cog thiab kev tso kawm, peb tau tsim cov qauv Ti-13Nb-13Zr alloy los ntawm kev hloov vanadium (V) nrog niobium (Nb), uas yog cov hlau tsis muaj mob, raws li daim ntawv tshaj tawm txog kev hloov pauv ntawm cov monomer (ASTM, ISO). Kuj tseem muaj qhov tau txais txiaj ntsig zoo thiab txhoj puab heev aluminium-tawm alloy uas yuav sai sai no.
